I use hytran in my font and rear diff on my pickup. I haven't run it very long like this, but a guy I work with has been running it in his ford for 250,000 miles with no problem. Its really noticeable in the wintertime. Hytran has more friction modifiers than gear oil does Plus CaseIH use it in some of there front diffs and planetaries so I don't see why a pickup could not use it. I would not use it in any transfer case that uses ATF because in really cold weather the oil could be to thick and ruin the pump, same goes for an auto tranny.
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