Are you planning on living here the rest of your life? If so, plan things around that can be changed as you get old-er. Being in a chair, I always look at others homes and think, "man what you going to do if/when you get old"? How you going to get around that house?
Wide doorways, lower windows, counters that you can sit under rather than alongside. Not a lot of steps outside. If you do an attached garage, make it level with the living quarters, instead of a step up.
Open bathrooms, not toilets stuck back in a corner.

Think of wider hallways, not the normal narrow ones.
In case you ever need to add a ramp, it'll be possible, instead of impossible, where you would have to move because your home couldn't be adapted.
Unfortunately, we are all going to get old someday, but when we are young, no one thinks of them days...
And when you figure your garage/toy-box, always think bigger, because it's never big enough, you run out of room real fast.